Anaerobic Biotransformation of Nitro-Compounds to Amines by Bovine Rumen Fluid
نویسندگان
چکیده
Microorganims of the bovine rumen fluid biocatalyzed the reduction of nitro-compound substrates to yield the respective amines. This enzymatic process, using ruminal contents, has rarely been reported in association with the bioreduction of nitro groups. The biotransformation reactions catalyzed by this system were dependent of both the electronic characteristics and the area/volume of the nitro-substrates confirming the processes are enzymatic. The semi-preparative scale biotransformation went by in good yield showing the rumen fluid may be employed in the synthesis of amines under very mild conditions and, moreover, it may have application in the bioremediation of nitro-compounds.
منابع مشابه
Biotransformation of Nitro Aromatic Compounds by Flavin-Free NADH-Azoreductase
Nitro aromatic compounds are the potential toxic organic pollutant released into the environment and are often resistant to degradation under normal environmental conditions. The biotransformation and/or detoxification of these compounds can be possible by microbial azoreductase enzyme. Azoreductase enzyme has an ability to reduce the toxic nitro group to corresponding amino group. In present r...
متن کاملReduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1.
Many aromatic amines and heterocyclic aromatic amines (HAAs) are known carcinogens for animals, and there is also strong evidence of some in human cancer. The activation of these compounds, including some arylamine drugs, involves N-hydroxylation, usually by cytochrome P450 enzymes (P450) in Family 1 (1A2, 1A1, and 1B1). We previously demonstrated that the bioactivation product of the anticance...
متن کاملToxicity of N-substituted aromatics to acetoclastic methanogenic activity in granular sludge.
N-substituted aromatics are important priority pollutants entering the environment primarily through anthropogenic activities associated with the industrial production of dyes, explosives, pesticides, and pharmaceuticals. Anaerobic treatment of wastewaters discharged by these industries could potentially be problematical as a result of the high toxicity of N-substituted aromatics. The objective...
متن کاملA chemoselective and green reduction of nitro arenes to aromatic amines with FeSO4, NaBH4, H3PW12O40 in water at room temperature
A new efficient and practical method for the room-temperature reduction of aromatic nitro compounds employing FeSO4. 7H2O, NaBH4, H3PW12O40 system in H2O under mild conditions is reported. The method is simple, inexpensive, easily scaled-up and applicable for the large scale preparation of different substituted anilines.
متن کاملBiodegradation of nitroaromatic compounds.
Nitroaromatic compounds are released into the biosphere almost exclusively from anthropogenic sources. Some compounds are produced by incomplete combustion of fossil fuels; others are used as synthetic intermediates, dyes, pesticides, and explosives. Recent research revealed a number of microbial systems capable of transforming or biodegrading nitroaromatic compounds. Anaerobic bacteria can red...
متن کامل